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Product Name : Fistent
Generic Name : Fulvestrant Injection 250mg
Manufacturer : Adley
Fulvestrant, sold under the brand name Faslodex amongothers, is a medication used to treat hormone receptor (HR)-positivemetastatic breast cancer in postmenopausal women with disease progression as well asHR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrinetherapy.It is given by injection into a muscle.
Medical usesFulvestrant is used for thetreatment of hormone receptor positive metastatic breast cancer or locallyadvanced unresectable disease in postmenopausal women; it is given byinjection. A 2017 Cochrane review found it is as safe and effective asfirst line or second line endocrine therapy.
It is also used to treatHR-positive, HER2-negative advanced or metastatic breast cancer in combinationwith palbociclib in women with disease progression after first-lineendocrine therapy.
Side effectsVery common (occurring in morethan 10% of people) adverse effects include nausea, injection site reactions,weakness, and elevatedtransaminases. Common (between 1% and 10%) adverseeffects include urinary tract infections, hypersensitivity reactions, loss ofappetite, headache, blood clots in veins, hot flushes, vomiting, diarrhea,elevated bilirubin, rashes, and backpain.
Fulvestrant is a selective estrogen receptordegrader (SERD).
It works by binding to theestrogen receptor and making it more hydrophobic, which makes the receptorunstable and misfold, which in turn leads normal processes inside the cell todegrade it.
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